Opening Ceremony
Amphitheater Mérieux 1&2

Welcome

• Xavier Martin, President of the Congress
• Thierry Berney, President of the IPITA, President of the Scientific Program Committee

Richard Lillehei lecture
Amphitheater Mérieux 1&2

Angelika Gruessner and Rainer Gruessner

Symposium on islet xenotransplantation
Amphitheater Mérieux 1&2
Supported by Diatranz Otsuka Ltd
Chair : Shinichi Matsumoto, Japan 

• Clinical update of islet transplantation at the University of Chicago
  Piotr Witkowski, University of Chicago, USA
• Challenges of regulatory issues in islet transplantation
  Barbara Barbaro, Chief Manufacturing Officer, Diatranz Otsuka Limited

Paul Lacy Lecture
Amphitheater Mérieux 1&2

Antonio Secchi

In this deliberately thought-provoking debate, young investigator 'cavemen' have the impossible task of challenging the wise yet ferocious 'dinosaurs' on a number of IPITA research areas, of which the dinosaurs have long been apex predators. Wish them luck!!

Battle 1:   Why have we not yet achieved immunological tolerance? Are you fooling us, or are you fooling yourselves!

Advances in Immunosuppressive drugs have continued to make transplantation a reality for many, with gradually lower and lower side effects. However the Holy Grail – ‘immunosuppression free and antigen-specific tolerance’ has yet to be achieved despite giant leaps in the understanding of immune function and mechanisms.

Challengers (cavemen): 1) Nathan Zammit 2) Alice Koenig
Dinosaurs: 1) Shane Grey 2) Qizhi Tang

Battle 2:  You dinosaurs will be considered butchers for doing pancreas transplants in the near future!

Pancreas transplantation has surreptitiously become the gold-standard treatment for patients with complicated insulin dependent diabetes mellitus. Outcomes have been improving, but given the continued significant morbidity, poor long-term outcomes and potential mortality and the lack of level 1 evidence supporting the procedure, in years to come, will we be able to defend ourselves for what we have done to our patients?

Challengers (cavemen): 1) Julien Brancherau 2) Raphael Meier
Dinosaurs: 1) Peter Stock 2) Jon Odorico

Battle 3:   Islet transplantation will be extinct, like you dinosaurs, before its full potential is realized! 

Despite great progresses (e.g. automated procedure, Edmonton protocol) islet transplantation remains an experimental procedure for many reasons. Still performed at a much lower rate than whole pancreas and is threatened by new prospects and promises of regenerative medicine. What future advances hold the key to unlocking islets true potential? 

Challengers (cavemen): 1) Adriana Migliorini 2) Christian Schuetz
Dinosaurs: 1) François Pattou 2) Eelco de Koning

PITCH presentation finals

• Role of Magnetic Resonance DTI in pancreas graft evaluation 
  A. Surowiecka-Pastewka1-3, K. Sklinda2, M. Matejak-Górska1, M. Frączek2, M. Durlik1-3, J. Walecki2
  1Department of Gastroenterological Surgery and Transplantation, Central Clinical Hospital of the Ministry of the Interior in Warsaw 2Departament of Radiology, Centre of Postgraduate Medical Education 3Department of Surgical Research and Transplantology, Mossakowski Medical Research Centre Polish Academy, Warsaw, Poland 
   
• Impact of ischemia time on islet isolation success and post-transplantation clinical outcomes: a retrospective study on 452 pancreas isolations
  C. Wassmer⁴, G. Parnaud⁴, K. Bellofatto⁴, F. Lebreton⁴, E. Brioudes⁴, L. Perez⁴, N. Pernin⁴, C. Rouget⁴, D. Matthey-Doret⁴, J. Loureiro⁴, C. Bosson⁴, PY. Benhamou¹, L. Kessler³, L. Badet², E. Berishvilli⁴, D. Bosco⁴, T. Berney⁴, V. Lavallard^{4
  1}Department of Endocrinology, Grenoble University Hospital, Grenoble University Hospital, Grenoble ²Hospices civils de Lyon, service d'urologie et de chirurgie de la transplantation, Lyon ³Department of Endocrinology and Diabetology, University Hospital of Strasbourg, Strasbourg University Hospital, Strasbourg, France ⁴Geneva University Hospital, Geneva, Switzerland 
   
• The incidence of fungal infections in pancreas transplant recipients in the absence of systemic antifungal prophylaxis
  S. Shaikh², P. Abrams¹, M. Cooper¹, A. Nolan^{2
  1}MedStar Georgetown Transplant Institute ²MedStar Georgetown University Hospital, Washington Dc, United States 
   
• Preservation of Pancreatic Islets with Stem Cell Derived CD34+ Vascular Endothelial Progenitor Cells
  C. Ward, L. Vo, E. De Klerk, G. Faleo, Y. Kelly, J. Bluestone, M. Hebrok, P. Stock, Q. Tang
  UCSF, San Francisco, United States 

• Formation of a Beta Cell Mass by Device-Encapsulated hiPS-Derived Pancreatic Endoderm Implanted in a Preformed Subcutaneous Pouch in Mice.
  T. Robert^1-2, I. De Mesmaeker^1-2, F. Van Hulle^1-2-3, K. Suenens², G. Stangé², Z. Ling^1-2-3, C. Haller⁴, N. Bouche⁴, B. Keymeulen^1-2-3, M. Kraus^1-4, D. Pipeleers^{1-2-3
  1}BetaCellTherapy consortium ²Diabetes Research Center, Brussels Free University-VUB ³University Hospital Brussels-UZB, Brussels, Belgium ⁴Nestlé Research, Lausanne, Switzerland 

• Effect of undercarboxylated osteocalcin on β-cell function and survival after islet isolation using obese vs non-obese pancreas donor in a murine model of islet transplantation
  MF. Desentis^6-2, AK. Robles-Murillo^6-2, LJ. Najar-Acosta^6-2, DA. Madrigal-Ruiz⁶, A. Zepeda-Moreno^3-4, FA. Sanchez-Zubieta^3-4, LC. León-Moreno^6-2, S. Sánchez-Enriquez⁵, JR. Villafán-Bernal¹, JD. Rivas-Carrillo^{6-2
  1}Department of Surgery, Center of Health Sciences, Autonomous University of Aguascalientes, Aguascalientes, Aguascalientes ²cGMP Cell Processing Facility, University Center of Health Sciences ³Child and Youth Cancer Research Institute, University Center of Health Sciences ⁴Department of Human Reproduction and Pediatrics, University Center of Health Sciences ⁵Department of Molecular Biology and Genomics, University Center of Health Sciences ⁶Department of Physiology, Laboratory of Tissue Engineering and Transplant, University Center of Health Sciences, Universidad of Guadalajara, Guadalajara, Jalisco, Mexico 
   
• Ex-situ hypothermic perfusion of non-human primates pancreas: an experimental model
  T. Prudhomme^1-3, K. Renaudin², S. Le Bas-Bernardet¹, D. Kervella^1-3, D. Cantarovich^1-3, G. Karam³, G. Blancho^1-3, J. Branchereau^{1-3
  1}Centre de Recherche en Transplantation et Immunologie, UMR 1064 ²Département d’Anatomie et Cytologie Pathologiques ³Institut de Transplantation Urologie Néphrologie, Nantes, France 
   
• Peri-trAnsplant INsulin Therapy to improve outcomes after pancrEas tRansplantation (PAINTER): an open-label randomised controlled trial
  I. Shapey^2-1, A. Summers^2-1, J. Bannard-Smith¹, T. Augustine^1-2, D. Van Dellen^1-2, M. Rutter^{2-1
  1}Manchester University NHS Foundation Trust ²University of Manchester, Manchester, United Kingdom