17th World Congress of the
INTERNATIONAL
PANCREAS & ISLET
TRANSPLANT ASSOCIATION

Lyon, Catholic University, 2-5 July 2019

 

 

 

 

Preliminary Scientific programDownload the program at a glance

 

  Download abstract book (.PDF)

 

Programme at a glance

 

Tuesday July 2, 2019
 
9.00 a.m. - 4.00 p.m.Aristote Amphitheatre
Pre-congress symposium
Amphitheater Aristote

The Igls criteria for defining pancreas and islet graft function: time for assessment
Organizing panel: Thierry Berney, Eelco de Koning, Lorenzo Piemonti, Michael Rickels, Peter Stock, Olivier Thaunat


9.00 - 10.00 a.m. - Session 1
Utility and utilization of the Igls criteria
Chairs: Thierry Berney, Michael Rickels

  • The Igls criteria: refresher
    Michael Rickels
  • Real-life application of the criteria: Issues and comparative results (pancreas vs islets)
    Reports from pancreas and islet transplant centers
    Axel Andres, Yvonne Kelly, Caterina Conte, Cyril Landstra
  • Interactive debate: what works and what doesn't

                              10.00 - 10.30 - Break

10.30 - 12.00 a.m. - Session 2
Assessment and improvement of the Igls criteria
Chairs: Eelco de Koning, Yogish Kudva

  • Pre-transplant metabolic assessment of the patient
    Michael Rickels
  • Should success criteria depend on the indication for beta cell replacement ?
    Patrik Choudhary
  • How can the Igls criteria be used to impact on patient management?
    Peter Senior
  • Should CGM parameters be included in a function score?
    Marie-Christine Vantyghem
  • Interactive debate: needs for improvement

  
                           12.00 - 13.00 - Lunch break


1.00 - 2.00 p.m. - Session 3
Immuno monitoring of beta cell replacement
Chairs: Peter Stock, Olivier Thaunat

  • Current immune monitoring practices
    Peter Stock
  • Significance of DSA monitoring of pancreas or islet grafts
    Olivier Thaunat
  • Pancreas graft biopsy
    Pablo Uva
  • Monitoring for autoimmunity
    George Burke


2.00 - 4.00 p.m. - Session 4
Expanding the application of the Igls criteria
Chairs: Lorenzo Piemonti, Thomas Kay

  • Applicability to islet autotransplants
    Melina Bellin
  • Assessing PTDM after beta-cell replacement
    Eelco de Koning
  • Comparing transplants with artificial pancreas: what metrics?
    Tom Kay
  • Definition of success as a function of risk
    Lorenzo Piemonti
  • Questions and discussion

2.00 - 5.00 p.m.
Salle de Cours
Nursing perspectives on the challenges of patient selection, graft survival and unique complications of Islet and pancreas transplantation
Chairs: Louise Berry (USA), Toni Radford (Australia)

 

This symposium highlights work achieved by the coordination and support teams in pancreas and islet transplantation units internationally. The intention of these sessions are both interactive and educational, leaving you with some thought provoking concepts and ideas as we venture through the journey of pancreas and islet transplantation. As Nursing and Allied Health professionals, we reap the benefits of attending this meeting and embrace professional developmental progression. These benefits are not limited to the gaining of knowledge and the networking process of such a widespread collaboration of professionals but will also enable us to provide support to others within the pancreas and islet transplantation field as they showcase their achievements through their presentations.

  • Welcome and outline
  • Getting to know your activity - Each attendee to introduce themselves, briefly outline their specialty area and role and describe their main motivation for doing the work they do
  • The role of the transplant co-coordinator - Solange Croyet (Switzerland)
  • Nursing/physician collaboration in islet pancres transplantation - Dr Ty Dunn (Philadelphia, USA)
  • The BTM-Alternative sites for islet transplantation - Chris Drogemuller (South Australia)

3.20 - 3.30 p.m.     Break

  • Smoking and weight management: Islet auto transplantation - Louise Berry (Minnesota, USA)
  • Hypoglycaemia after islet cell transplantation - Dr Melena Bellin, endocrinologist (Minnesota, USA)
  • Life after transplant - What happens to our patients outside of the hospital clinic ? - Toni Radford (South Australia)
  • Patient expenrience: Life before and after my Allo Islet transplant - Marie-Louise Mandl (London, UK)
  • Group discussion: shared experiences

YIC Pre-congress Workshop
Rockefeller campus

Stream 1 - Ecole de Chirurgie
Clinical cases in Pancreas Procurement

Stream 2 - CLESS,  médiathèque Paul Zech
Simulation of islet infusion and complications

Stream 3 - Room CIER 106
Discussions in cutting edge advances in Islet and Pancreas Transplantation

 
5.00 - 6.30 p.m.

Opening Ceremony
Amphitheater Mérieux 1&2


Welcome

  • Xavier Martin, President of the Congress
  • Thierry Berney, President of the IPITA, President of the Scientific Program Committee

Lectures "What is left of Claude Bernard in the Internet era ?" 
Pierre Corvol, President of the French Academy of Sciences
  "Artificial Intelligence in medicine: the good, the bad, the ugly"
Christian Lovis, University Hospital of Geneva, Division of Medical Information Sciences
 
6.30 - 8.00 p.m.
Welcome cocktail
 
Wednesday July 3, 2019
 
7.00 - 7.45 a.m.
Morning run - Meeting point "Place Carnot Park, near statue de la République"
 
8.15-9.45 a.m.

Plenary session 1 – Talk show
Amphitheater Mérieux 1&2

Opening the echo chamber - Perspectives on curing diabetes
Hosted by: Peter Senior (Edmonton, Canada) and Hussein Khambalia (Manchester, UK)

  • What do patients with diabetes really want?
  • Can (could) this be met by islet, pancreas, stem cell replacement?
  • What are patients with diabetes building for themselves?
  • How should we compare the different options ?
  • Can clinical trial results be generalized to all patients with type 1 diabetes ?
  • Who should be recruited to clinical trials ?
Panelists Kate Farnsworth, Canada
  Jonathan Fridell, Indianapolis,USA
  Frantisek Saudek, Prague, Czech republic
  Tadej Batellino, Ljubljana, Slovenia
 
9.45 - 10.15 a.m.

Richard Lillehei lecture
Amphitheater Mérieux 1&2

Angelika Gruessner and Rainer Gruessner

 
10.15 - 10.45 a.m.
Coffee break and exhibition visit
 
10.45 - 11.30 a.m.

Symposium on islet xenotransplantation
Amphitheater Mérieux 1&2

Supported by Diatranz Otsuka Ltd
Chair : Shinichi Matsumoto, Japan 

  • Clinical update of islet transplantation at the University of Chicago
    Piotr Witkowski, University of Chicago, USA
  • Challenges of regulatory issues in islet transplantation
    Barbara Barbaro, Chief Manufacturing Officer, Diatranz Otsuka Limited
 
10.45 a.m. - 12.15 p.m.
Oral Communications 1 & 2
 
11.30 a.m. - 12.15 p.m.
Pitch 1, 2, 3 & 4
 
12.15 - 1.15 p.m.
Lunch Break
 
1.15 - 2.15 p.m.
Mini-oral 1, 2, 3 & 4
 
2.15 - 3.45 p.m.

State of the Art 1
Amphitheater Mérieux 3

Organ preservation « Out of the box »
Chairs: Matthew Cooper (USA), Wayne Hawthorne (Australia)

  • Sorting criteria for the marginal pancreas: waste or recondition ?
    Raja Kandaswamy, Minneapolis, USA
  • Normothermic regional perfusion of pancreas and islet donors
    Andrew Sutherland, Edinburgh, UK
  • Hypothermic oxygenated machine perfusion in pancreas/islet transplantation
    Vassilios Papalois, London, UK
  • Oxygen persufflation : a feasible and efficient technique for pancreas reconditioning ?
    Klearchos Papas, Tucson, USA

State of the Art 2
Amphitheater Aristote

Biotechnology shapes the future for beta cell replacement therapy
Chairs: Hanne Scholz (Norway), Ekaterine Berishvili (Georgia)

  • “House of islets”
    Lorenzo Piemonti, Italy
  • Bioengineering approach to immunosuppression-free islet transplantation
    Haval Shirwan, Louisville, USA
  • Generation of organoids from human pancreatic cells
    Eelco de Koning, Leiden, The Netherlands
 
3.45 - 4.15 p.m.
Coffee break and exhibition visit
 
4.15 - 5.45 p.m.
Oral Communications 3,4,5 & 6
 
5.45 - 6.30 p.m.
IPITASciPub.
 
Thursday July 4, 2019
 
6.45 - 7.45 a.m.
Morning run - Meeting point "Place Carnot Park, near statue de la République"
 
8.15 - 9.45 a.m.

Plenary session 2
Amphitheater Mérieux 1&2

Hypes and hopes of the artificial pancreas
Chairs: Thierry Berney (Switzerland), Pierre-Yves Benhamou (France)

  • Current automated insulin delivery systems : what do they really achieve ?
    Alanna Weisman, Toronto, Canada
  • Patient-driven R&D : why-how-what ?
    Kate Farnsworth, Bolton, Canada
  • Comparison of the DBLHU Closed-Loop Insulin Delivery with Low-Glucose-Predictive-Suspend system in adults with very unstable type 1 diabetes: A Feasibility and Safety trial
    Pierre-Yves Benhamou, Grenoble, France
  • Risk-benefit assessment of beta-cell replacement vs automated insulin delivery systems
    Patrik Choudhary, London, UK
 
9.45 - 10.15 a.m.
Presidential address/Derek Gray Awards
Amphitheater Mérieux 1&2
 
10.15 - 10.45 a.m.
Coffee break and exhibition visit
 
10.45 a.m. - 12.15 p.m.
Oral Communications 7, 8, 9 & 10
 
12.15 - 1.15 p.m.
Lunch Break
 
12.15 - 1.15 p.m.
IPITA business Meeting Amphitheater Mérieux 1&2
 
1.15 - 2.15 p.m.
Mini-oral 5, 6, 7 & 8
 
2.15 - 3.45 p.m.

State of the Art 3
Amphitheater Mérieux 3

Letter to the (gene) editor
Chairs: Shane Grey (Australia), Nathan Zammit (Australia)

  • Genome editing made easy (« Genome editing for dummies » ?)
    Danwei Huangfu, New-York, USA
  • Will gene editing carry pig islets to the clinic ?
    Eckhard Wolf, Munich, Germany
  • Can genome editing produce "universal human cells" for transplantation ?
    Gregory Block, Seattle, USA

State of the Art 4
Amphitheater Aristote

Type 2 diabetes: a surgical disease ?
Chairs: François Pattou (France), Mike Rickels (USA)

  • Phenotypic variability in type 2 diabetes
    Stefano Del Prato, Pisa, Italy
  • Bariatric surgery : reviving the failing beta cells in type 2 diabetes
    Eric Wise, Minneapolis, USA
  • Pancreas transplantation : replacing the failing beta cells in type 2 diabetes
    Jon S. Odorico, Madison, USA
 
3.45 - 4.15 p.m.
Coffee break and exhibition visit
 
4.15 - 5.45 p.m.
Oral Communications 11, 12, 13 & 14
 
5.45 - 6.30 p.m.
IPITASciPub.
 
7.00 - 11.00 p.m.
YIC networking event
 
Friday July 5, 2019
 
6.45 - 7.45 a.m.
Morning run - Meeting point "Place Carnot Park, near statue de la République"
 
8.15 - 9.45 a.m.

State of the Art 5
Amphitheater Mérieux 3

Sponsored by Astellas Pharma

Immunosuppression tailored for beta-cell replacement
Chair: Olivier Thaunat (France)

  • Immunometabolism and beta cell replacement
    Marc Donath, Basel, Switzerland
  • Strategies for beta cell replacement: Pancreas vs Islet
    Peter Stock, San Francisco, USA
  • Precision medicine in immunosuppression: how hard can it be ? 
    Dorry Segev, USA
  • Tolerance induction in beta cell replacement
    Qizhi Tang, San Francisco, USA

State of the Art 6
Amphitheater Aristote

Keeping an eye on beta cells : biomarkers to monitor pancreas and islet grafts
Chairs: Shane Grey (Australia), Eelco de Koning (The Netherlands)

  • Imaging beta cells in vivo
    Olof Eriksson, Uppsala, Sweden
  • Alternate transplantation sites to monitor islet histology
    Toby Coates, Adelaide, Australia
  • Immune monitoring of signs of rejection and diabetes recurrence
    Paolo Monti, Milan, Italy
  • Genomics of beta cell death
    Bashoo Naziruddin, Dallas, USA
 
9.45 - 10.15 a.m.

Paul Lacy Lecture
Amphitheater Mérieux 1&2

Antonio Secchi

 
10.15 - 10.45 a.m.
Coffee break and exhibition visit
 
10.45 - 11.45 a.m.
Oral Communications 15, 16, 17 & 18
 
11.45 - 12.45 p.m.
Dinosaur Challenge
Amphitheater Mérieux 1&2

In this deliberately thought-provoking debate, young investigator 'cavemen' have the impossible task of challenging the wise yet ferocious 'dinosaurs' on a number of IPITA research areas, of which the dinosaurs have long been apex predators. Wish them luck!!

Battle 1:   Why have we not yet achieved immunological tolerance? Are you fooling us, or are you fooling yourselves!

Advances in Immunosuppressive drugs have continued to make transplantation a reality for many, with gradually lower and lower side effects. However the Holy Grail – ‘immunosuppression free and antigen-specific tolerance’ has yet to be achieved despite giant leaps in the understanding of immune function and mechanisms.

Challengers (cavemen): 1) Nathan Zammit 2) Alice Koenig
Dinosaurs: 1) Shane Grey 2) Qizhi Tang

Battle 2:  You dinosaurs will be considered butchers for doing pancreas transplants in the near future!

Pancreas transplantation has surreptitiously become the gold-standard treatment for patients with complicated insulin dependent diabetes mellitus. Outcomes have been improving, but given the continued significant morbidity, poor long-term outcomes and potential mortality and the lack of level 1 evidence supporting the procedure, in years to come, will we be able to defend ourselves for what we have done to our patients?

Challengers (cavemen): 1) Julien Brancherau 2) Raphael Meier
Dinosaurs: 1) Peter Stock 2) Jon Odorico

Battle 3:   Islet transplantation will be extinct, like you dinosaurs, before its full potential is realized! 

Despite great progresses (e.g. automated procedure, Edmonton protocol) islet transplantation remains an experimental procedure for many reasons. Still performed at a much lower rate than whole pancreas and is threatened by new prospects and promises of regenerative medicine. What future advances hold the key to unlocking islets true potential? 

Challengers (cavemen): 1) Adriana Migliorini 2) Christian Schuetz
Dinosaurs: 1) François Pattou 2) Eelco de Koning

 
12.45 - 1.30 p.m.
Lunch Break
 
1.30 - 3.30 p.m.

Plenary session 3
Amphitheater Mérieux 1&2

Beta cell grafts for all
Chairs: Lorenzo Piemonti (Italy), James Markmann (USA)

  • Novel immunomodulatory approaches for porcine islet xenotransplantation
    Chung Gyu Park, Seoul, Korea
     
  • Organ manufacturing by interspecies blastocyst complementation
    Juan Carlos Izpisua Belmonte, San Diego, USA
     
  • Challenges and opportunities in bioengineering, advanced microfabrication, 3D printing and beta cell replacement devices
    Aart van Appeldorn, Maastricht, The Netherlands
  • Challenges and opportunities of hESC-derived β cells for T1D therapy
    Cristina Nostro, Toronto, Canada
  • Re-create beta cell development in a dish – a source for future cell therapy
    Henrik Semb, Copenhagen, Denmark
 
3.30 - 3.45 p.m.
Coffee Break
 
3.45 - 4.45 p.m.

PITCH presentation finals

  • Role of Magnetic Resonance DTI in pancreas graft evaluation 
    A. Surowiecka-Pastewka1-3, K. Sklinda2, M. Matejak-Górska1, M. Frączek2, M. Durlik1-3, J. Walecki2
    1Department of Gastroenterological Surgery and Transplantation, Central Clinical Hospital of the Ministry of the Interior in Warsaw 2Departament of Radiology, Centre of Postgraduate Medical Education 3Department of Surgical Research and Transplantology, Mossakowski Medical Research Centre Polish Academy, Warsaw, Poland 
     
  • Impact of ischemia time on islet isolation success and post-transplantation clinical outcomes: a retrospective study on 452 pancreas isolations
    C. Wassmer4, G. Parnaud4, K. Bellofatto4, F. Lebreton4, E. Brioudes4, L. Perez4, N. Pernin4, C. Rouget4, D. Matthey-Doret4, J. Loureiro4, C. Bosson4, PY. Benhamou1, L. Kessler3, L. Badet2, E. Berishvilli4, D. Bosco4, T. Berney4, V. Lavallard4
    1Department of Endocrinology, Grenoble University Hospital, Grenoble University Hospital, Grenoble 2Hospices civils de Lyon, service d'urologie et de chirurgie de la transplantation, Lyon 3Department of Endocrinology and Diabetology, University Hospital of Strasbourg, Strasbourg University Hospital, Strasbourg, France 4Geneva University Hospital, Geneva, Switzerland 
     
  • The incidence of fungal infections in pancreas transplant recipients in the absence of systemic antifungal prophylaxis
    S. Shaikh2, P. Abrams1, M. Cooper1, A. Nolan2
    1MedStar Georgetown Transplant Institute 2MedStar Georgetown University Hospital, Washington Dc, United States 
     
  • Preservation of Pancreatic Islets with Stem Cell Derived CD34+ Vascular Endothelial Progenitor Cells
    C. Ward, L. Vo, E. De Klerk, G. Faleo, Y. Kelly, J. Bluestone, M. Hebrok, P. Stock, Q. Tang
    UCSF, San Francisco, United States 
  • Formation of a Beta Cell Mass by Device-Encapsulated hiPS-Derived Pancreatic Endoderm Implanted in a Preformed Subcutaneous Pouch in Mice.
    T. Robert1-2, I. De Mesmaeker1-2, F. Van Hulle1-2-3, K. Suenens2, G. Stangé2, Z. Ling1-2-3, C. Haller4, N. Bouche4, B. Keymeulen1-2-3, M. Kraus1-4, D. Pipeleers1-2-3
    1BetaCellTherapy consortium 2Diabetes Research Center, Brussels Free University-VUB 3University Hospital Brussels-UZB, Brussels, Belgium 4Nestlé Research, Lausanne, Switzerland 
  • Effect of undercarboxylated osteocalcin on β-cell function and survival after islet isolation using obese vs non-obese pancreas donor in a murine model of islet transplantation
    MF. Desentis6-2, AK. Robles-Murillo6-2, LJ. Najar-Acosta6-2, DA. Madrigal-Ruiz6, A. Zepeda-Moreno3-4, FA. Sanchez-Zubieta3-4, LC. León-Moreno6-2, S. Sánchez-Enriquez5, JR. Villafán-Bernal1, JD. Rivas-Carrillo6-2
    1Department of Surgery, Center of Health Sciences, Autonomous University of Aguascalientes, Aguascalientes, Aguascalientes 2cGMP Cell Processing Facility, University Center of Health Sciences 3Child and Youth Cancer Research Institute, University Center of Health Sciences 4Department of Human Reproduction and Pediatrics, University Center of Health Sciences 5Department of Molecular Biology and Genomics, University Center of Health Sciences 6Department of Physiology, Laboratory of Tissue Engineering and Transplant, University Center of Health Sciences, Universidad of Guadalajara, Guadalajara, Jalisco, Mexico 
     
  • Ex-situ hypothermic perfusion of non-human primates pancreas: an experimental model
    T. Prudhomme1-3, K. Renaudin2, S. Le Bas-Bernardet1, D. Kervella1-3, D. Cantarovich1-3, G. Karam3, G. Blancho1-3, J. Branchereau1-3
    1Centre de Recherche en Transplantation et Immunologie, UMR 1064 2Département d’Anatomie et Cytologie Pathologiques 3Institut de Transplantation Urologie Néphrologie, Nantes, France 
     
  • Peri-trAnsplant INsulin Therapy to improve outcomes after pancrEas tRansplantation (PAINTER): an open-label randomised controlled trial
    I. Shapey2-1, A. Summers2-1, J. Bannard-Smith1, T. Augustine1-2, D. Van Dellen1-2, M. Rutter2-1
    1Manchester University NHS Foundation Trust 2University of Manchester, Manchester, United Kingdom
 
4.45 - 5.00 p.m.
Conclusions Amphitheater Mérieux 1&2

DRWF - Diabetes Research & Wellness Foundation
 
7.30 p.m.
Congress dinner
 

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