| Tuesday July 2, 2019 |
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| 9.00 a.m. - 4.00 p.m. |
Pre-congress symposium
The Igls criteria for defining pancreas and islet graft function: time for assessment
Organizing panel: Thierry Berney, Eelco de Koning, Lorenzo Piemonti, Michael Rickels, Peter Stock, Olivier Thaunat
9.00 - 10.00 a.m. - Session 1
Utility and utilization of the Igls criteria
Chairs: Thierry Berney, Michael Rickels
- The Igls criteria: refresher
Michael Rickels
- Real-life application of the criteria: Issues and comparative results (pancreas vs islets)
Reports from pancreas and islet transplant centers
10.00 - 10.30 - Break
10.30 - 12.00 a.m. - Session 2
Assessment and improvement of the Igls criteria
Chairs: Eelco de Koning, James Shaw
- Pre-transplant metabolic assessment of the patient
Roger Lehmann
- Should success criteria depend on the indication for beta cell replacement ?
Patrik Choudhary
- How can the Igls criteria be used to impact on patient management?
to be confirmed
- Should CGM parameters be included in a function score?
Marie-Christine Vantyghem
- Interactive debate: needs for improvement
12.00 - 13.00 - Lunch break
1.00 - 2.00 p.m. - Session 3
Immuno monitoring of beta cell replacement
Chairs: Peter Stock, Olivier Thaunat
- Current immune monitoring practices
Peter Stock
- Significance of DSA monitoring of pancreas or islet grafts
Olivier Thaunat
- Pancreas graft biopsy
Pablo Uva
- Monitoring for autoimmunity
George Burke
2.00 - 4.00 p.m. - Session 4
Expanding the application of the Igls criteria
Chairs: Lorenzo Piemonti, Tom Kay
- Applicability to islet autotransplants
Melina Bellin
- Assessing PTDM after beta-cell replacement
Eelco de Koning
- Comparing transplants with artificial pancreas: what metrics?
Tom Kay
- Definition of success as a function of risk
Lorenzo Piemonti
- Questions and discussion
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2.00 - 5.00 p.m.
Nursing perspectives on the challenges of patient selection, graft survival and unique complications of Islet and pancreas transplantation
Chairs: Louise Berry (USA), Toni Radford (Australia)
This symposium highlights work achieved by the coordination and support teams in pancreas and islet transplantation units internationally. The intention of these sessions are both interactive and educational, leaving you with some thought provoking concepts and ideas as we venture through the journey of pancreas and islet transplantation. As Nursing and Allied Health professionals, we reap the benefits of attending this meeting and embrace professional developmental progression. These benefits are not limited to the gaining of knowledge and the networking process of such a widespread collaboration of professionals but will also enable us to provide support to others within the pancreas and islet transplantation field as they showcase their achievements through their presentations.
- Welcome and outline
- Getting to know your activity - Each attendee to introduce themselves, briefly outline their specialty area and role and describe their main motivation for doing the work they do
- The role of the transplant co-coordinator - Solange Croyet (Switzerland)
- Nursing/physician collaboration in islet pancres transplantation - Dr Ty Dunn (Philadelphia, USA)
- The BTM-Alternative sites for islet transplantation - Chris Drogemuller (South Australia)
3.20 - 3.30 p.m. Break
- Smoking and weight management: Islet auto transplantation - Louise Berry (Minnesota, USA)
- Hypoglycaemia after islet cell transplantation - Dr Melena Bellin, endocrinologist (Minnesota, USA)
- Life after transplant - What happens to our patients outside of the hospital clinic ? - Toni Radford (South Australia)
- Patient expenrience: Life before and after my Allo Islet transplant - Marie-Louise Mandl (London, UK)
- Group discussion: shared experiences
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YIC Pre-congress Workshhop
Rockefeller campus
Stream 1 - Clinical cases in Pancreas Procurement
Stream 2 - Simulation of islet infusion and complications
Stream 3 - Discussions in cutting edge advances in Islet and Pancreas Transplantation
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| 5.00 - 6.30 p.m. |
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Opening Ceremony
Welcome
- Xavier Martin, President of the Congress
- Thierry Berney, President of the IPITA, President of the Scientific Program Committee
- DRWF - Diabetes Research & Wellness Foundation
| Lecture |
Pierre Corvol, President of the French Academy of Sciences |
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| 6.30 - 8.00 p.m. |
| Welcome cocktail |
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| Wednesday July 3, 2019 |
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| 7.00 - 7.45 a.m. |
| Morning run |
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| 8.30-9.45 a.m. |
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Plenary session 1 – Talk show
Opening the echo chamber - Perspectives on curing diabetes
Hosts: Peter Senior (Canada), Hussein Khambalia (UK)
- What do patients with diabetes really want?
- Can (could) this be met by islet, pancreas, stem cell replacement?
- What are patients with diabetes building for themselves?
- How should we compare the different options ?
- Can cinical trial results be generalized to all patients with type 1 diabetes ?
- Who should be recruited to clinical trials ?
| Panellists |
Karen Denoyer, New York, USA |
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Jonathan Fridell, Indianapolis,USA |
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Frantisek Saudek, Prague, Czech republic |
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Tadej Batellino, Ljubljana, Slovenia |
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| 9.45 - 10.15 a.m. |
| Richard Lillehei lecture |
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| 10.15 - 10.45 a.m. |
| Coffee break and exhibition visit |
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| 10.45 - 11.30 a.m. |
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Symposium on islet xenotransplantation
Supported by Diatranz Otsuka Ltd
Chair : Shinichi Matsumoto, Japan
- Clinical update of islet transplantation at the University of Chicago
Piotr Witkowski, University of Chicago, USA
- Challenges of regulatory issues in islet transplantation
Barbara Barbaro, Chief Manufacturing Officer, Diatranz Otsuka Limited
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| 10.45 a.m. - 12.15 p.m. |
| Oral Communications 1 & 2 |
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| 11.30 a.m. - 12.15 p.m. |
| Pitch 1, 2, 3 & 4 |
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| 12.15 - 1.15 p.m. |
| Lunch Break |
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| 1.15 - 2.15 p.m. |
| Mini-oral 1, 2, 3 & 4 |
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| 2.15 - 3.45 p.m. |
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State of the Art 1
Organ preservation « Out of the box »
Chairs: Matthew Cooper (USA), Wayne Hawthorne (Australia)
- Sorting criteria for the marginal pancreas: waste or recondition ?
Raja Kandaswamy, Minneapolis, USA
- Normothermic regional perfusion of pancreas and islet donors
Andrew Sutherland, Edinburgh, UK
- Hypothermic oxygenated machine perfusion in pancreas/islet transplantation
VassiliosPapalois, London, UK
- Oxygen persufflation : a feasible and efficient technique for pancreas reconditioning ?
Klearchos Papas, Tucson, USA
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State of the Art 2
Biotechnology shapes the future for beta cell replacement therapy
Chairs: Hanne Scholz (Norway), Ekaterine Berishvili (Georgia)
- “House of islets”
Lorenzo Piemonti, Italy
- Bioengineering approach to immunosuppression-free islet transplantation
Haval Shirwan, Louisville, USA
- Generation of insulin-producing cells from human pancreatic organoids
Eelco de Koning, Leiden, The Netherlands
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| 3.45 - 4.15 p.m. |
| Coffee break and exhibition visit |
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| 4.15 - 5.45 p.m. |
| Oral Communications 3,4,5 & 6 |
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| 5.45 - 6.30 p.m. |
| IPITASciPub. |
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| Thursday July 4, 2019 |
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| 7.00 - 7.45 a.m. |
| Morning run |
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| 8.30 - 9.45 a.m. |
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Plenary session 2
Hypes and hopes of the artificial pancreas
Chairs: Thierry Berney (Switzerland), Pierre-Yves Benhamou (France)
- Current automated insulin delivery systems : what do they really achieve ?
Alanna Weisman, Toronto, Canada
- Patient-driven R&D : why-how-what ?
Kate Farnsworth, Bolton, Canada
- What will it take to address uncontrolled diabetes with closed-loop technology ?
Eric Renard, Montpellier, France
- Risk-benefit assessment of beta-cell replacement vs automated insulin delivery systems
Patrik Choudhary, London, UK
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| 9.45 - 10.15 a.m. |
| Presidential address/Derek Gray Awards |
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| 10.15 - 10.45 a.m. |
| Coffee break and exhibition visit |
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| 10.45 a.m. - 12.15 p.m. |
| Oral Communications 7, 8, 9 & 10 |
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| 12.15 - 1.15 p.m. |
| Lunch Break |
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| 12.15 - 1.15 p.m. |
| IPITA business Meeting |
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| 1.15 - 2.15 p.m. |
| Mini-oral 5, 6, 7 & 8 |
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| 2.15 - 3.45 p.m. |
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State of the Art 3
Letter to the (gene) editor
Chairs: Jon Odorico (USA), Nathan Zammit (Australia)
- Genome editing made easy (« Genome editing for dummies » ?)
Danwei Huangfu, New-York, USA
- Will gene editing carry pig islets to the clinic ?
Eckhard Wolf, Munich, Germany
- Can genome editing produce "universal human cells" for transplantation ?
Gregory Block, Seattle, USA
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State of the Art 4
Type 2 diabetes: a surgical disease ?
Chairs: François Pattou (France), Mike Rickels (USA)
- Phenotypic variability in type 2 diabetes
Stefano Del Prato, Pisa, Italy
- Bariatric surgery : reviving the failing beta cells in type 2 diabetes
Sayeed Ikramuddin, Minneapolis, USA
- Pancreas transplantation : replacing the failing beta cells in type 2 diabetes
Jon S. Odorico, Madison, USA
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| 3.45 - 4.15 p.m. |
| Coffee break and exhibition visit |
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| 4.15 - 5.45 p.m. |
| Oral Communications 11, 12, 13 & 14 |
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| 5.45 - 6.30 p.m. |
| IPITASciPub. |
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| 7.00 - 11.00 p.m. |
| YIC networking event |
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| Friday July 5, 2019 |
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| 7.00 - 7.45 a.m. |
| Morning run |
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| 8.30 - 9.45 a.m. |
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State of the Art 5
Sponsored by Astellas Pharma
Immunosuppression tailored for beta-cell replacement
Chair: Olivier Thaunat (France)
- Immunometabolism and beta cell replacement
Marc Donath, Basel, Switzerland
- Strategies for beta cell replacement: Pancreas vs Islet
Peter Stock, San Francisco, USA
- Precision medicine in immunosuppression: how hard can it be ?
Dorry Segev, USA
- Tolerance induction in beta cell replacement
Qizhi Tang, San Francisco, USA
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State of the Art 6
Keeping an eye on beta cells : biomarkers to monitor pancreas and islet grafts
Chairs: Shane Grey (Australia), Eelco de Koning (The Netherlands)
- Imaging beta cells in vivo
Olof Eriksson, Uppsala, Sweden
- Alternate transplantation sites to monitor islet histology
Toby Coates, Adelaide, Australia
- Immune monitoring of signs of rejection and diabetes recurrence
Paolo Monti, Milan, Italy
- Genomics of beta cell death
Bashoo Naziruddin, Dallas, USA
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| 9.45 - 10.15 a.m. |
| Paul Lacy Lecture |
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| 10.15 - 10.45 a.m. |
| Coffee break and exhibition visit |
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| 10.45 - 11.45 a.m. |
| Oral Communications 15, 16, 17 & 18 |
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| 11.45 - 12.45 p.m. |
| Dinosaur Challenge |
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| 12.45 - 1.45 p.m. |
| Lunch Break |
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| 1.45 - 2.45 p.m. |
| PITCH presentation finals |
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| 2.45 - 4.45 p.m. |
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Plenary session 3
Beta cell grafts for all
Chairs: Lorenzo Piemonti (Italy), James Markmann (USA)
- Novel immunomodulatory approaches for porcine islet xenotransplantation
Chung Gyu Park, Seoul, Korea
- Organ manufacturing by interspecies blastocyst complementation
Juan Carlos Izpisua Belmonte, San Diego, USA
- Islet 3-D bioprinting
Aart van Appeldorn, Maastricht, The Netherlands
- Challenges and opportunities of hESC-derived β cells for T1D therapy
Cristina Nostro, Toronto, Canada
- Re-create beta cell development in a dish – a source for future cell therapy
Henrik Semb, Copenhagen, Denmark
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| 4.45 - 5.15 p.m. |
| Conclusions |
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| 7.00 p.m. |
| Congress dinner |
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