| Tuesday July 2, 2019 |
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| 9.00 a.m. - 4.00 p.m. |
Pre-congress symposium
The Igls criteria for defining pancreas and islet graft function: time for assessment
Organizing panel: Thierry Berney, Eelco de Koning, Lorenzo Piemonti, Michael Rickels, Peter Stock, Olivier Thaunat
9.00 - 10.00 a.m. - Session 1
Utility and utilization of the Igls criteria
Chairs: Thierry Berney, Michael Rickels
- The Igls criteria: refresher
Michael Rickels
- Real-life application of the criteria: Issues and comparative results (pancreas vs islets)
Reports from pancreas and islet transplant centers
10.00 - 10.30 - Break
10.30 - 12.00 a.m. - Session 2
Assessment and improvement of the Igls criteria
Chairs: Eelco de Koning, James Shaw
- Pre-transplant metabolic assessment of the patient
Roger Lehmann
- Should success criteria depend on the indication for beta cell replacement ?
Patrik Choudhary
- How can the Igls criteria be used to impact on patient management?
James Shaw
- Should CGM parameters be included in a function score?
Marie-Christine Vantyghem
- Interactive debate: needs for improvement
12.00 - 13.00 - Lunch break
1.00 - 2.00 p.m. - Session 3
Immuno monitoring of beta cell replacement
Chairs: Peter Stock, Olivier Thaunat
- Current immune monitoring practices
Peter Stock
- Significance of DSA monitoring of pancreas or islet grafts
Olivier Thaunat
- Pancreas graft biopsy
Pablo Uva
- Monitoring for autoimmunity
George Burke
2.00 - 4.00 p.m. - Session 4
Expanding the application of the Igls criteria
Chairs: Lorenzo Piemonti, Tom Kay
- Applicability to islet autotransplants
Melina Bellin
- Assessing PTDM after beta-cell replacement
Eelco de Koning
- Comparing transplants with artificial pancreas: what metrics?
Tom Kay
- Definition of success as a function of risk
Lorenzo Piemonti
- Questions and discussion
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YIC Pre-congress Workshhop
Rockefeller campus
Stream 1 - Clinical cases in Pancreas Procurement
Stream 2 - Islet perfusion and complications simulation
Stream 3 - Discussions in cutting edge advances in Islet and Pancreas Transplantation
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| 5.00 - 6.30 p.m. |
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Opening Ceremony
| Lectures |
Pierre Corvol, President of the Science Academy |
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David Kerr, Sansum Diabetes Research Institute, Santa Barbara, CA, USA |
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| 6.30 - 8.00 p.m. |
| Welcome cocktail |
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| Wednesday July 3, 2019 |
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| 7.30 - 8.30 a.m. |
| Morning run |
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| 8.30-10.00 a.m. |
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Plenary session 1 – Talk show
Opening the echo chamber - Perspectives on curing diabetes
- What do patients with diabetes really want?
- Can (could) this be met by islet, pancreas, stem cell replacement?
- What are patients with diabetes building for themselves?
- How should we compare the different options ?
- Can cinical trial results be generalized to all patients with type 1 diabetes ?
- Who should be recruited to clinical trials ?
| Panellists |
Karen Denoyer, New York, USA |
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Jonathan Fridell, Indianapolis,USA |
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Frantisek Saudek, Prague, Czech republic |
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Tadej Batellino, Ljubljana, Slovenia |
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| 10.00 - 10.30 a.m. |
| Richard Lillehei lecture |
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| 10.30 - 11.00 a.m. |
| Coffee break |
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| 11.00 - 11.45 a.m. |
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Symposium on islet xenotransplantation
Supported by Diatranz Otsuka Ltd
Chair : Shinichi Matsumoto, Japan
- Clinical update of islet transplantation at the University of Chicago
Piotr Witkowski, University of Chicago, USA
- Challenges of regulatory issues in islet transplantation
Barbara Barbaro, University of Illinois, Chicago, USA
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| 11.00 a.m. - 12.30 p.m. |
| Oral Communications |
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| 12.30 - 1.30 p.m. |
| Lunch Break |
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| 1.30 - 2.00 p.m. |
| PITCH |
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| 2.00 - 3.30 p.m. |
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State of the Art 1
Organ preservation « Out of the box »
- Sorting criteria for the marginal pancreas: waste or recondition ?
Raja Kandaswamy, Minneapolis, USA
- Normothermic regional perfusion of pancreas and islet donors
Andrew Sutherland, Edinburgh, UK
- Hypothermic oxygenated machine perfusion in pancreas/islet transplantation
VassiliosPapalois, London, UK
- Oxygen persufflation : a feasible and efficient technique for pancreas reconditioning ?
Klearchos Papas, Tucson, USA
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State of the Art 2
Biotechnology shapes the future for beta cell replacement therapy
- “House of islets”
Lorenzo Piemonti, Italy
- Bioengineering approach to immunosuppression-free islet transplantation
Haval Shirwan, Louisville, USA
- Generation of insulin-producing cells from human pancreatic organoids
Eelco de Koning, Leiden, The Netherlands
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| 3.30 - 5.00 p.m. |
| Oral Communications |
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| 5.00 - 6.00 p.m. |
| IPITASciPub. |
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| Thursday July 4, 2019 |
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| 7.30 - 8.30 a.m. |
| Morning run |
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| 8.30 - 10.00 a.m. |
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Plenary session 2
Hypes and hopes of the artificial pancreas
- Current automated insulin delivery systems : what do they really achieve ?
Alanna Weisman, Toronto, Canada
- Patient-driven R&D : why-how-what ?
Kate Farnsworth, Bolton, Canada
- What will it take to address uncontrolled diabetes with closed-loop technology ?
Eric Renard, Montpellier, France
- Risk-benefit assessment of beta-cell replacement vs automated insulin delivery systems
Patrik Choudhary, London, UK
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| 10.00 - 10.30 a.m. |
| Presidential address/Derek Gray Awards |
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| 10.30 - 11.00 a.m. |
| Coffee break |
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| 11.00 a.m. - 12.30 p.m. |
| Oral Communications |
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| 12.30 - 1.30 p.m. |
| Lunch Break |
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| 1.30 - 2.00 p.m. |
| IPITA Business meeting |
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| 2.00 - 3.30 p.m. |
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State of the Art 3
Letter to the (gene) editor
- Genome editing made easy (« Genome editing for dummies » ?)
Danwei Huangfu, New-York, USA
- Will gene editing carry pig islets to the clinic ?
Eckhard Wolf, Munich, Germany
- Can genome editing produce "universal human cells" for transplantation ?
Gregory Block, Seattle, USA
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State of the Art 4
Type 2 diabetes: a surgical disease ?
- Phenotypic variability in type 2 diabetes
Stefano Del Prato, Pisa, Italy
- Bariatric surgery : reviving the failing beta cells in type 2 diabetes
speaker to be confirmed
- Pancreas transplantation : replacing the failing beta cells in type 2 diabetes
Dixon Kaufmann, Madison, USA
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| 3.30 - 5.00 p.m. |
| Oral Communications |
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| 5.00 - 6.00 p.m. |
| IPITASciPub. |
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| 7.00 - 11.00 p.m. |
| YIC networking event |
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| Friday July 5, 2019 |
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| 7.30-8.30 a.m. |
| Morning run |
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| 8.30-10.00 a.m. |
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State of the Art 5
Immunosuppression tailored for beta-cell replacement
- Immunometabolism and beta cell replacement
Marc Donath, Basel, Switzerland
- Strategies for beta cell replacement: Pancreas vs Islet
Peter Stock, San Francisco, USA
- Precision medicine in immunosuppression: how hard can it be ?
speaker to be confirmed
- Tolerance induction in beta cell replacement
Qizhi Tang, San Francisco, USA
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State of the Art 6
Keeping an eye on beta cells : biomarkers to monitor pancreas and islet grafts
- Imaging beta cells in vivo
Olof Eriksson, Uppsala, Sweden
- Alternate transplantation sites to monitor islet histology
Toby Coates, Adelaide, Australia
- Immune monitoring of signs of rejection and diabetes recurrence
Paolo Monti, Milan, Italy
- Genomics of beta cell death
Bashoo Naziruddin, Dallas, USA
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| 10.00 - 10.30 a.m. |
| Paul Lacy Lecture |
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| 10.30 - 11.00 a.m. |
| Coffee break |
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| 11.00 - 12.00 a.m. |
| Oral Communications |
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| 12.00 - 1.00 p.m. |
| Dinausor Challenge |
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| 1.00 - 2.00 p.m. |
| Lunch Break |
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| 2.00 - 3.00 p.m. |
| PITCH presentation finals |
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| 3.00 - 5.00 p.m. |
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Plenary session 3
Beta cell grafts for all
- Organ manufacturing by interspecies blastocyst complementation
Juan Carlos Izpisua Belmonte, San Diego, USA
- Islet 3-D bioprinting
Aart van Appeldorn, Maastricht, The Netherlands
- Challenges and opportunities of hESC-derived β cells for T1D therapy
Cristina Nostro, Toronto, Canada
- Re-create beta cell development in a dish – a source for future cell therapy
Henrik Semb, Copenhagen, Denmark
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| 5.00 - 5.30 p.m. |
| Conclusions |
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| 7.00 p.m. |
| Congress dinner |
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